Antimicrobial constituents from fruits ofAilanthus altissima SWINGLE
- 1 October 2005
- journal article
- research article
- Published by Springer Science and Business Media LLC in Archives of Pharmacal Research
- Vol. 28 (10), 1147-1151
- https://doi.org/10.1007/bf02972977
Abstract
A new naturally occurring sterol, compound5, and six known stigmasterols were isolated from fruits ofAilanthus altissima Swingle by repeated column chromatography and RP-HPLC. Their structures were identified as, 5α-stigmastane-3,6-dione (1), 3β-hydroxystigmast-5-en-7-one (2), stigmast-5-ene-3β, 7α-diol (3), 6α-hydroxystigmast-4-en-3-one (4), 5α-stigmastane-3β, 6β-diol (5), stigmast-4-ene-3β, 6α-diol (6), stigmast-5-ene-3β, 7α,20ζ-triol (7) by spectral analysis and comparison with the published data. These compounds have not been reported from genusAilanthus, whereas compound7 was identified by NMR for the first time. In addition, the 95% ethanol extract and compounds from the fruits of Ailanthus altissima SWINGLE were assayed forin vitro antimicrobial activity. The extract was potent active against the assayed bacteria while compounds3 and7 exhibited moderate activity.Keywords
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