Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment
Top Cited Papers
Open Access
- 1 March 2015
- journal article
- research article
- Published by Georg Thieme Verlag KG in Archives of Plastic Surgery
- Vol. 42 (02), 232-239
- https://doi.org/10.5999/aps.2015.42.2.232
Abstract
A foreign body granuloma is a non-allergic chronic inflammatory reaction that is mainly composed of multinucleated giant cells. Foreign body granulomas may occur after the administration of any dermal filler. Factors such as the volume of the injection, impurities present in the fillers, and the physical properties of fillers affect granuloma formation. The formation of granulomas involves five phases: protein adsorption, macrophage adhesion, macrophage fusion, and crosstalk. The clinical and pathologic features of granulomas vary depending on the type of filler that causes them. Foreign body granulomas can be treated effectively with intralesional corticosteroid injections. Surgical excisions of granulomas tend to be incomplete because granulomas have ill-defined borders and moreover, surgical excisions may leave scars and deformities.Keywords
This publication has 48 references indexed in Scilit:
- Inflammatory granuloma caused by injectable soft tissue filler (Artecoll)Journal of the Korean Association of Oral and Maxillofacial Surgeons, 2013
- The Therapeutic Benefit of Allopurinol in the Treatment of Foreign Body Granulomas Caused by Polymethylmethacrylate MicrospheresCase Reports in Dermatological Medicine, 2012
- The Biology of Facial FillersFacial Plastic Surgery, 2009
- Foreign body reaction to biomaterialsSeminars in Immunology, 2007
- Facial paraffinoma after cosmetic paraffin injectionThe Journal of Dermatology, 2007
- Delayed immune‐mediated adverse effects related to hyaluronic acid and acrylic hydrogel dermal fillers: clinical findings, long‐term follow‐up and review of the literatureJournal of the European Academy of Dermatology and Venereology, 2007
- Successful colchicine administration in facial granulomas caused by cosmetic implants: Report of a caseJournal of Dermatological Treatment, 2007
- Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary studyInternational Journal of Dermatology, 2005
- Silicone granuloma of the face treated with minocyclineJournal of the American Academy of Dermatology, 2005
- Paraffinoma in anterior abdominal wall mimicking liposarcomaThe British Journal of Radiology, 2003