Neutrophil Elastase Activity Is Associated with Exacerbations and Lung Function Decline in Bronchiectasis
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- 15 May 2017
- journal article
- research article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 195 (10), 1384-1393
- https://doi.org/10.1164/rccm.201605-1027oc
Abstract
Rationale: Sputum neutrophil elastase and serum desmosine, which is a linked marker of endogenous elastin degradation, are possible biomarkers of disease severity and progression in bronchiectasis. This study aimed to determine the association of elastase activity and desmosine with exacerbations and lung function decline in bronchiectasis.Keywords
This publication has 45 references indexed in Scilit:
- Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasisMolecular Immunology, 2012
- Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular trapsThe Journal of cell biology, 2010
- British Thoracic Society guideline for non-CFbronchiectasisThorax, 2010
- Human Neutrophil Peptides and Phagocytic Deficiency in Bronchiectatic LungsAmerican Journal of Respiratory and Critical Care Medicine, 2009
- Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanismsEuropean Respiratory Journal, 2008
- Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and ElaborationPLoS Medicine, 2007
- Association between Pulmonary Function and Sputum Biomarkers in Cystic FibrosisAmerican Journal of Respiratory and Critical Care Medicine, 2007
- The role of secretory leucoprotease inhibitor in the resolution of inflammatory responsesBiochemical Society Transactions, 2007
- Standardisation of spirometryEuropean Respiratory Journal, 2005
- CT findings in bronchiectasis: limited value in distinguishing between idiopathic and specific types.American Journal of Roentgenology, 1995