Adverse Events Reported Following Live, Cold-Adapted, Intranasal Influenza Vaccine

Abstract
Annual influenza vaccination is the primary method for protection against influenza illness.1 Until the 2002-2003 influenza season, the only licensed influenza vaccine in the United States was the inactivated, trivalent injectable vaccine, with recommendations emphasizing use among individuals for whom influenza is of particular concern.1,2 In June 2003, the US Food and Drug Administration (FDA) licensed a trivalent live, attenuated influenza vaccine (LAIV-T [FluMist, MedImmune Vaccines Inc, Gaithersburg, Md]) for intranasal use among healthy persons 5 to 49 years of age.3 Each dose contains live attenuated influenza virus reassortants of the 3 strains recommended by the US Public Health Service for the corresponding influenza season.2,3