A systematic overview of published antimalarial drug trials.
- 1 February 2004
- journal article
- review article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 98 (2), 73-81
- https://doi.org/10.1016/s0035-9203(03)00014-2
Abstract
Systematic database searches identified 435 antimalarial drug treatment trials, involving 82 616 patients, conducted and published between 1966 and December 2002. Of these trials 72% were randomised; 64 (15%) trials involved severe malaria, 47 (11%) studied Plasmodium vivax, 3 Plasmodium malariae or Plasmodium ovale, and the remainder (74%) assessed treatment responses in uncomplicated falciparum malaria. Twelve trials (2.7%) specifically evaluated antimalarial treatments in pregnant women. Overall 49% of trials were conducted in Asia (29% from Thailand alone) and 42% in Africa. Half of all the patients studied had been in trials published in the past 7 years. There has been a recent rise in the proportion of trial enrolling children, and a tripling in the average number of patients recruited per trial (from approximately 100 in the 1970s to 300 currently). Chloroquine was given to over half the patients in antimalarial drug trials (n=53552) compared with artemisinin derivatives (n=12463), mefloquine-sulphadoxine-pyrimethamine (n=9153), mefloquine (n=5546) and sulphadoxine-pyrimethamine (n=5909). The quality of safety and efficacy data for recently evaluated drugs contrasts with a relative paucity of data for older ‘established’ compounds.Keywords
This publication has 10 references indexed in Scilit:
- The assessment of antimalarial drug efficacyTrends in Parasitology, 2002
- Contribution of humoral immunity to the therapeutic response in falciparum malaria.The American Journal of Tropical Medicine and Hygiene, 2001
- Clinical and neurophysiological study of the effects of multiple doses of artemisinin on brain-stem function in Vietnamese patients.The American Journal of Tropical Medicine and Hygiene, 2000
- A case-control auditory evaluation of patients treated with artemisinin derivatives for multidrug-resistant Plasmodium falciparum malaria.The American Journal of Tropical Medicine and Hygiene, 2000
- No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine.The American Journal of Tropical Medicine and Hygiene, 1999
- Treatment Of Multidrug-Resistant Plasmodium Falciparum Malaria With 3-Day Artesunate-Mefloquine CombinationThe Journal of Infectious Diseases, 1994
- Fatal Hepatic Necrosis Due to Pyrimethamine-Sulfadoxine (Fansidar)Annals of Internal Medicine, 1987
- Severe Cutaneous Reactions among American Travelers Using Pyrimethamine-Sulfadoxine (Fansidar®) for Malaria ProphylaxisThe American Journal of Tropical Medicine and Hygiene, 1986
- FREQUENCY OF SEVERE NEUTROPENIA ASSOCIATED WITH AMODIAQUINE PROPHYLAXIS AGAINST MALARIAThe Lancet, 1986
- Observations on malaria made during treatment of general paralysisTransactions of the Royal Society of Tropical Medicine and Hygiene, 1924