THE INTERACTION BETWEEN POLYSACCHARIDES AND OTHER MACROMOLECULES. 4. THE OSMOTIC PRESSURE OF MIXTURES OF SERUM ALBUMIN AND HYALURONIC ACID
- 1 November 1963
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 89 (2), 249-253
- https://doi.org/10.1042/bj0890249
Abstract
An investigation of the osmotic behavior of mixtures of hyaluronic acid and serum albumin has shown that their osmotic pressures are significantly greater than the sum of the osmotic pressures of solutions containing hyaluronic acid and serum albumin separately at the same concentrations. A thermodynamic analysis of the results shows that they are self-consistent in form and reasonably so with regard to independent estimates of certain parameters. The results can be interpreted in terms of an "exclusion" of albumin from part of the solution occupied by hyaluronic acid. The excluded volume was calculated to be approximately 25 ml. of hyaluronic acid/g. at low polysaccharide concentrations.Keywords
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