Xanthine Oxidase Status in Ethanol-Intoxicated Rat Liver
- 1 December 1989
- journal article
- research article
- Published by Wiley in Alcohol: Clinical and Experimental Research
- Vol. 13 (6), 841-844
- https://doi.org/10.1111/j.1530-0277.1989.tb00434.x
Abstract
The status of xanthine oxidase in ethanol-induced liver injury has been investigated in the rat, by acute and chronic ethanol treatments. A 38% increase of the enzyme O-form was observed after repeated ethanol administration. Chronic intoxication caused a significant decrease of total xanthine oxidase activity after both prolonged ethanol feeding and life span ethanol ingestion. The intermediate D/O-form of xanthine oxidase (that can act either as an oxidase or as a dehydrogenase, being able to react with O2 as well as with NAD+ as electron acceptor14,16) increased 5.5-fold after prolonged ethanol feeding.This publication has 28 references indexed in Scilit:
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