Inflammasomes: mechanism of assembly, regulation and signalling
Top Cited Papers
- 13 June 2016
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 16 (7), 407-420
- https://doi.org/10.1038/nri.2016.58
Abstract
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals in the cytosol of host cells, and they activate inflammatory caspases to produce cytokines and to induce pyroptotic cell death. The clinical importance of inflammasomes reaches beyond infectious disease, as dysregulated inflammasome activity is associated with numerous hereditary and acquired inflammatory disorders. In this Review, we discuss the recent developments in inflammasome research with a focus on the molecular mechanisms that govern inflammasome assembly, signalling and regulation.Keywords
This publication has 132 references indexed in Scilit:
- Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome ActivationCell Reports, 2013
- NLRP6 negatively regulates innate immunity and host defence against bacterial pathogensNature, 2012
- Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 ReceptorImmunity, 2012
- Innate and Adaptive Interferons Suppress IL-1α and IL-1β Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis InfectionImmunity, 2011
- Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in MiceImmunity, 2011
- NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for ColitisCell, 2011
- IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus InfectionCell Host & Microbe, 2011
- The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing proteinEuropean Journal of Human Genetics, 2011
- Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine ProcessingCell Host & Microbe, 2010
- Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage CytosolCell Host & Microbe, 2010