Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients
- 16 September 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 136 (3), 427-435
- https://doi.org/10.1007/s00432-009-0673-6
Abstract
The purpose of this study was to investigate the co-expression of survivin, c-erbB2, and COX-2 in endometrial cancer tissues and evaluate its prognostic significance in endometrial cancer Tumor tissue biopsies from 110 patients with primary untreated endometrial carcinomas were studied by immunohistochemistry. Statistical analysis evaluated correlation of antigen expression with tumor stage, grade, myometrial invasion, and histologic type. Association with disease outcome was also investigated The results showed that expression of the three antigens was independently associated with histological grade, disease stage, and myometrial invasion. Clinicopathological parameters were also associated with the number of antigens expressed by each tumor, the expression of more antigens correlating with advanced stage disease and deep myometrial invasion. In a 10-year follow-up, patients with tumors expressing more of these three antigens had significantly lower survival rate that those with smaller expression score Our results indicate that the co-expression score has independent prognostic value for endometrial cancer.Keywords
This publication has 27 references indexed in Scilit:
- Cytoplasmic Expression of c-erb-B2 in Endometrial CarcinomasOncology Research and Treatment, 2007
- COX-2 and survivin are overexpressed and positively correlated in endometrial carcinomaGynecologic Oncology, 2007
- Correlation of ErbB2 Gene Status, mRNA and Protein Expression in a Panel of >100 Human Tumor Xenografts of Different OriginOncology Research and Treatment, 2006
- Expression of survivin, PTEN and p27 in normal, hyperplastic, and carcinomatous endometriumInternational Journal of Gynecologic Cancer, 2006
- Emerging issues of the expression profiling technologies for the study of gynecologic cancerAmerican Journal of Obstetrics and Gynecology, 2005
- Expression of cyclooxygenase-2 (COX-2), receptors for estrogen (ER), and progesterone (PR), p53, ki67, and neu protein in endometrial cancerGynecologic Oncology, 2005
- Correlation of cyclooxygenase-2 (COX-2) and aromatase expression in human endometrial cancer: Tissue microarray analysisAmerican Journal of Obstetrics and Gynecology, 2005
- Gene expression profiling in human endometrial cancer tissue samples: utility and diagnostic valueGynecologic Oncology, 2004
- Cyclooxygenase‐2 expression in endometrial carcinomaCancer, 2002
- Estrogens and glucocorticoids induce the expression of c-erbB2/NEU receptor in ishikawa human endometrial cellsLife Sciences, 1997