The neuropathy of plasma cell dyscrasia
- 1 October 1985
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 35 (10), 1420
- https://doi.org/10.1212/wnl.35.10.1420
Abstract
In some patients with neuropathy and plasma cell dyscrasia, the M-proteins bind to peripheral nerves. Binding of M-proteins to peripheral nerve glycolipids was examined by immunostaining after thin-layer chromatography. The IgM from 16 patients with anti-MAG M-proteins bound to the same two glycolipid bands in peripheral nerve. The IgM that bound to the glycolipids had the same idiotype as the anti-MAG M-protein, indicating that it was the M-protein that bound to both glycolipids. The reactive glycolipids did not contain sialic acid and were not gangliosides. No immunostaining of peripheral nerve glycolipids was observed with IgM from patients with neuropathy and IgM M-proteins that did not bind to MAG, and the anti-MAG antibodies did not bind to brain glycolipids. Anti-MAG M-proteins probably bind to the same or closely related carbohydrate determinants that are shared by a number of glycoproteins and glycolipids of peripheral nerve.This publication has 22 references indexed in Scilit:
- Polyneuropathy in nonmalignant IgM plasma cell dyscrasia: A Morphological studyAnnals of Neurology, 1983
- Monoclonal IgM K antibody precipitating with chondroitin sulfate C from patients with axonal polyneuropathy and epidermolysisNeurology, 1983
- Neuropathy accompanying IgM? monoclonal gammopathyActa Neuropathologica, 1983
- Demyeliating neuropathy and monoclonal IgM antibody to myelin‐associated glycoproteinNeurology, 1983
- Immunocytochemical studies of human peripheral nerve with serum from patients with polyneuropathy and paraproteinemiaNeurology, 1982
- The genetic basis of antibody production: The dominant anti‐arsonate idiotype response of the strain a mouseEuropean Journal of Immunology, 1982
- A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibodyCell, 1981
- I and i antigens of human peripheral blood lymphocytes cocap with receptors for concanavalin A.Proceedings of the National Academy of Sciences of the United States of America, 1980
- Macroglobulinaemia in an Icelandic FamilyActa Medica Scandinavica, 1978
- Quantitive estimation of sialic acidsBiochimica et Biophysica Acta, 1957