Low Incidence of a Nucleotide Sequence Alteration of the Neurofibromatosis 2 Gene in Human Breast Cancers
- 1 October 1995
- journal article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 86 (10), 929-933
- https://doi.org/10.1111/j.1349-7006.1995.tb03003.x
Abstract
We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single‐strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor‐specific single‐base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.Keywords
This publication has 28 references indexed in Scilit:
- Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomasHuman Molecular Genetics, 1994
- Germline mutations in the neurofibromatosis type 2 tumour suppressor geneHuman Molecular Genetics, 1994
- The neurofibromatosis 2 (NF2) tumor suppressor gene encodes multiple alternatively spliced transcriptsHuman Molecular Genetics, 1994
- Exon scanning for mutation of the NF2 gene in schwannomasHuman Molecular Genetics, 1994
- Somatic NF2 gene mutations in familial and non-familial vestibular schwannomaHuman Molecular Genetics, 1994
- Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour typesNature Genetics, 1994
- Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomasNature Genetics, 1994
- Heterogeneity for Allelic Loss in Human Breast CancerJNCI Journal of the National Cancer Institute, 1992
- Neurofibromatosis 2New England Journal of Medicine, 1988
- Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA PolymeraseScience, 1988