THE INFLUENCE OF BARBITURATE ANAESTHESIA UPON THE ENERGY STATE AND UPON ACID-BASE PARAMETERS OF THE BRAIN IN ARTERIAL HYPOTENSION AND IN ASPHYXIA
- 1 May 1971
- journal article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 47 (2), 233-253
- https://doi.org/10.1111/j.1600-0404.1971.tb07479.x
Abstract
The influence of barbiturate anaesthesia upon the energy and acid-base metabolism of the brain was studied in arterial hypotension and in asphyxia by measuring the tissue concentrations of phosphocreatine, ATP, ADP, AMP, lactate, pyruvate, and bicarbonate. Intracellular lactate and pyruvate concentrations were derived after corrections for the lactate and pyruvate contained in the blood and extracellular fluid volumes of the tissue. Barbiturate anaesthesia was found to have a protective effect during arterial hypotension but not during total asphyxia.Keywords
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