Discovery of new azaindole-based PI3Kα inhibitors: Apoptotic and antiangiogenic effect on cancer cells
- 26 October 2010
- journal article
- research article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 20 (24), 7212-7215
- https://doi.org/10.1016/j.bmcl.2010.10.108
Abstract
No abstract availableKeywords
This publication has 26 references indexed in Scilit:
- 5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-α and mTOR for the treatment of breast cancerBioorganic & Medicinal Chemistry Letters, 2010
- A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitorsBioorganic & Medicinal Chemistry Letters, 2010
- Exploring the PI3Kα and γ binding sites with 2,6-disubstituted isonicotinic derivativesBioorganic & Medicinal Chemistry Letters, 2009
- Discovery of 5-pyrrolopyridinyl-2-thiophenecarboxamides as potent AKT kinase inhibitorsBioorganic & Medicinal Chemistry Letters, 2009
- Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migrationNature, 2008
- A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in gliomaCancer Cell, 2006
- Deficiency in the p110α subunit of PI3K results in diminished Tie2 expression and Tie2-/-–like vascular defects in miceBlood, 2005
- High Frequency of Mutations of the PIK3CA Gene in Human CancersScience, 2004
- The Phosphoinositide 3-Kinase PathwayScience, 2002
- Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapyThe British Journal of Radiology, 1993