Serum concentrations of risperidone and 9‐OH risperidone following intramuscular injection of long‐acting risperidone compared with oral risperidone medication
- 7 June 2006
- journal article
- research article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 114 (1), 21-26
- https://doi.org/10.1111/j.1600-0447.2006.00840.x
Abstract
To compare serum concentrations of risperidone, 9-hydroxy (OH) risperidone and risperidone plus 9-OH risperidone, as well as the 9-OH risperidone/risperidone ratio in patients receiving depot and oral risperidone. Serum concentrations from 78 patients receiving three different doses of risperidone depot were measured and compared with serum concentrations from 82 patients taking three different doses of oral risperidone. Patients receiving risperidone depot had significantly lower serum concentrations of risperidone plus 9-OH risperidone than patients taking oral risperidone. More interestingly, the 9-OH risperidone/risperidone ratio was also significantly lower in patients receiving risperidone depot than in patients taking oral risperidone. Serum concentrations of risperidone plus 9-OH risperidone may be a rather poor indication of the antipsychotic efficacy of risperidone unless their ratio is also considered.Keywords
This publication has 35 references indexed in Scilit:
- Therapeutic drug monitoring of patients on risperidone depotNordic Journal of Psychiatry, 2005
- Serum Concentrations of Risperidone and 9-Hydroxyrisperidone After Administration of the Long-Acting Injectable Form of RisperidoneTherapeutic Drug Monitoring, 2005
- Clinical review of a long-acting, injectable formulation of risperidoneClinical Therapeutics, 2004
- Early Clinical Experience With Risperidone Long-Acting InjectionThe Journal of Clinical Psychiatry, 2004
- Patients with schizophrenia previously stabilized on conventional depot antipsychotics experience significant clinical improvements following treatment with long-acting risperidoneEuropean Psychiatry, 2004
- Depot risperidone for schizophreniaPublished by Wiley ,2003
- A Pilot Study on Risperidone MetabolismThe Journal of Clinical Psychiatry, 1999
- Pharmacokinetics and D2 receptor occupancy of long-acting injectable risperidone (Risperdal Consta™) in patients with schizophreniaInternational Journal of Neuropsychopharmacology, 1999
- The Relationship Between Serum Concentration and Therapeutic Effect of Haloperidol in Patients with Acute SchizophreniaClinical Pharmacokinetics, 1998
- Clinical Pharmacokinetics of the Depot AntipsychoticsClinical Pharmacokinetics, 1985