Antihyperglycemic and antioxidative effects of the hydro-methanolic extract of the seeds of Caesalpinia bonduc on streptozotocin-induced diabetes in male albino rats
Open Access
- 1 January 2012
- journal article
- research article
- Published by EManuscript Technologies in Pharmacognosy Research
- Vol. 4 (1), 57-62
- https://doi.org/10.4103/0974-8490.91044
Abstract
Background: No satisfactory effective treatment is available yet to cure diabetes mellitus. Though, synthetic drugs are used but there are several drawbacks. The attributed antihyperglycemic effects of many traditional plants are due to their ability for the management of diabetes mellitus. Materials and Methods: A hydromethanolic extract was administered orally at a dose of 250 mg/kg of body weight per day for 21 days. Its effects on the fasting blood glucose (FBG) level, activities of key carbohydrate metabolic enzymes like hexokinase, glucose-6-phosphatase, and glucose-6-phosphate dehydrogenase, and antioxidant enzymes like catalase and superoxide dismutase along with the effect on the lipid peroxidation level in hepatic tissues were measured. Glycogen levels were also assessed in hepatic and skeletal muscles and some toxicity parameters, such as serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, and alkaline phosphates activities were measured. Results: Treatment of the hydromethanolic extract of the seeds of Caesalpinia bonduc resulted in a significant (P < 0.05) recovery in the activities of carbohydrate metabolic enzymes along with correction in FBG and glycogen levels as compared with the untreated diabetic group. The extract also resulted in a significant (P < 0.05) recovery in the activities of toxicity assessment enzyme parameters. Activities of antioxidant enzymes like catalase and superoxide dismutase along with the lipid peroxidation levels were also recovered significantly (P < 0.05) after the treatment of the extract. The corrective effects produced by the extract were compared with the standard antidiabetic drug, glibenclamide. Conclusion: Our findings provide that the extract shows possible antihyperglycemic and antioxidative activities.Keywords
This publication has 25 references indexed in Scilit:
- Anti-hyperglycemic and anti-oxidative effect of aqueous extract of Momordica charantia pulp and Trigonella foenum graecum seed in alloxan-induced diabetic rats.2010
- The antihyperglycemic effect of aerial parts of Salvia splendens (scarlet sage) in streptozotocin-induced diabetic-ratsPharmacognosy Research, 2010
- Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino ratsInternational Journal of Ayurveda Research, 2010
- Antifilarial activity of Caesalpinia bonducella against experimental filarial infections.2008
- Therapeutic effect of ferulic acid, an ethereal fraction of ethanolic of seed of Syzygium cumini against streptozotocin-induced diabetes in male ratMethods and Findings in Experimental and Clinical Pharmacology, 2008
- Diabetes, oxidative stress, and antioxidants: A reviewJournal of Biochemical and Molecular Toxicology, 2003
- Brain lipid peroxidation and hydroxy radical attack following the intravenous infusion of hydrogen peroxide in an infantFree Radical Biology & Medicine, 1996
- A review on some antidiabetic plants of India.1995
- Decreased lipid peroxidation in the rat kidney during gestationBiochemical and Biophysical Research Communications, 1987
- Glutathione Peroxidase: Effect of Superoxide, Hydroxyl and Bromine Free Radicals on Enzyme ActivityInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1980