Nonselective cyclo-oxygenase inhibitors and glomerular filtration rate in preterm neonates
- 16 August 2005
- journal article
- research article
- Published by Springer Science and Business Media LLC in Pediatric Nephrology
- Vol. 20 (11), 1557-1561
- https://doi.org/10.1007/s00467-005-1998-2
Abstract
The adverse effects of nonselective cyclo-oxygenase (COX) inhibitors on the immature kidney have been described in newborn rabbits, but it is much more laborious and difficult to study its relative impact on renal function in human neonates. Amikacin clearance was therefore used as surrogate marker to study the impact of nonselective COX-inhibitors on glomerular filtration rate. Clinical characteristics and amikacin clearance of infants on respiratory support were retrospectively collected. Results in neonates in whom either ibuprofen-lysine or acetylsalicylic acid was administered prophylactically to induce closure of a patent asymptomatic ductus arteriosus were compared to infants not cotreated with any COX-inhibitor (Mann-Whitney U-, chi-square tests). Amikacin clearance was calculated in 142 infants, of whom 50 were cotreated with ibuprofen and 33 with acetylsalicylic acid. There were no significant differences in clinical characteristics between the three groups. Compared to controls (0.52, range 0.09–2.33 ml/kg/min), a significant similar decrease in amikacin clearance in infants cotreated with ibuprofen (0.38, range 0.13–0.80 ml/kg/min, p p<0.01) was demonstrated. Using amikacin clearance as marker, a significant and similar reduction in glomerular filtration rate was documented in preterm infants cotreated with ibuprofen or acetylsalicylic acid.Keywords
This publication has 16 references indexed in Scilit:
- The impact of ibuprofen on renal clearance in preterm infants is independent of the gestational agePediatric Nephrology, 2005
- Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trialThe Lancet, 2004
- Quantitative justification for target concentration intervention – parameter variability and predictive performance using population pharmacokinetic models for aminoglycosidesBritish Journal of Clinical Pharmacology, 2004
- Long-Term Effects of Indomethacin Prophylaxis in Extremely-Low-Birth-Weight InfantsNew England Journal of Medicine, 2001
- A Comparison of Ibuprofen and Indomethacin for Closure of Patent Ductus ArteriosusNew England Journal of Medicine, 2000
- Gentamicin pharmacokinetics in neonates with patent ductus arteriosusCritical Care Medicine, 1997
- Serum creatinine concentration, urinary creatinine excretion and creatinine clearance during the first 9 weeks in preterm infants with a birth weight below 1500 gEuropean Journal of Pediatrics, 1996
- Aspirin versus Indomethacin Treatment of Patent Ductus Arteriosus in Preterm Infants with Respiratory Distress SyndromePediatric Research, 1995
- Glomerular filtration rate in the preterm infant: the relation to gestational and postnatal ageEuropean Journal of Pediatrics, 1988
- Effects of Continuous Positive Airway Pressure on Renal Function in PrematuresNeonatology, 1983