ABCA1-Deficient Mice
Open Access
- 1 June 2003
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 23 (6), 972-980
- https://doi.org/10.1161/01.atv.0000054661.21499.fb
Abstract
Studies with ATP-binding cassette transporter (ABCA1)–deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on atherosclerosis.Keywords
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