SOME EFFECTS OF HUMAN GROWTH HORMONE ON RENAL HEMODYNAMICS AND ON TUBULAR PHOSPHATE TRANSPORT IN MAN*

Abstract

Human growth hormone (HGH) administered to eleven human subjects during usually four days, under conditions of metabolic balance regimen, raised significantly the renal plasma flow (RPF), the glomerular filtration rate (GFR), the maximal tubular reabsorption of phosphate (TMp) and the maximal reabsorption of phosphate per ml of filtrate ([image]). The rise in [image] indicates that HGH enhances tubular reabsorption of phosphorus independently of any action on filtration of phosphorus. The authors conclude that the decrease in phosphaturia and the rise in serum phosphorus observed in their subjects during HGH treatment are of renal origin. They also suggest that growth hormone is responsible for the elevation of serum phosphorus found in acromegaly and that this is effected by an increase in the reabsorption of filtered phosphorus.