Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol
Open Access
- 31 March 2011
- journal article
- Published by Springer Science and Business Media LLC in Nanoscale Research Letters
- Vol. 6 (1), 275
- https://doi.org/10.1186/1556-276x-6-275
Abstract
Novel mixed polymeric micelles formed from biocompatible polymers, poly(ethylene glycol)-poly(lactide) (mPEG-PLA) and polyoxyethylene-660-12-hydroxy stearate (Solutol HS15), were fabricated and used as a nanocarrier for solubilizing poorly soluble anesthetic drug propofol. The solubilization of propofol by the mixed micelles was more efficient than those made of mPEG-PLA alone. Micelles with the optimized composition of mPEG-PLA/Solutol HS15/propofol = 10/1/5 by weight had particle size of about 101 nm with narrow distribution (polydispersity index of about 0.12). Stability analysis of the mixed micelles in bovine serum albumin (BSA) solution indicated that the diblock copolymer mPEG efficiently protected the BSA adsorption on the mixed micelles because the hydrophobic groups of the copolymer were efficiently screened by mPEG, and propofol-loaded mixed micelles were stable upon storage for at least 6 months. The content of free propofol in the aqueous phase for mixed micelles was lower by 74% than that for the commercial lipid emulsion. No significant differences in times to unconsciousness and recovery of righting reflex were observed between mixed micelles and commercial lipid formulation. The pharmacological effect may serve as pharmaceutical nanocarriers with improved solubilization capacity for poorly soluble drugs.Keywords
This publication has 39 references indexed in Scilit:
- Preparation and Evaluation of Poly(Ethylene Glycol)–Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine ANanoscale Research Letters, 2010
- Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug EthaselenNanoscale Research Letters, 2009
- Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugsEuropean Journal of Pharmaceutics and Biopharmaceutics, 2006
- Anesthetic Properties of a Propofol Microemulsion in DogsAnesthesia & Analgesia, 2006
- Changes in Concentrations of Free Propofol by Modification of the SolutionAnesthesia & Analgesia, 2005
- Core-Cross-Linked Polymeric Micelles as Paclitaxel CarriersBioconjugate Chemistry, 2004
- Reducing Pain During Propofol InjectionAnesthesia & Analgesia, 1996
- Poly(styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe studyMacromolecules, 1991
- PropofolDrugs, 1988
- Hypernatraemic dehydration and necrotizing enterocolitisPostgraduate Medical Journal, 1985