A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder
- 1 October 2009
- journal article
- research article
- Published by Wiley in Autism Research
- Vol. 2 (5), 246-257
- https://doi.org/10.1002/aur.97
Abstract
Magnetic resonance imaging (MRI) and postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross‐sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to “plane of section artifacts” may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI's were acquired from 62 male participants (7.5 to 18.5 years‐old) who met criteria for the following age‐matched diagnostic groups: low functioning autism, high functioning autism (HFA), Asperger syndrome, and typically developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders.Keywords
This publication has 43 references indexed in Scilit:
- Magnetic Resonance Imaging Outcomes From a Comprehensive Magnetic Resonance Study of Children With Fetal Alcohol Spectrum DisordersAlcohol: Clinical and Experimental Research, 2009
- FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformationNature Genetics, 2009
- Cerebellar vermal volumes and behavioral correlates in children with autism spectrum disorderPsychiatry Research: Neuroimaging, 2009
- A Structural MRI Study of Human Brain Development from Birth to 2 YearsJournal of Neuroscience, 2008
- Brain morphometry volume in autistic spectrum disorder: a magnetic resonance imaging study of adultsPsychological Medicine, 2008
- Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studiesEuropean Psychiatry, 2008
- Neuropathology of infantile autismMolecular Psychiatry, 2002
- Quantitative Magnetic Resonance Imaging of Human Brain Development: Ages 4–18Cerebral Cortex, 1996
- Hypoplasia of the cerebellar vermis in neurogenetic syndromesAnnals of Neurology, 1996
- Hypoplasia of Cerebellar Vermal Lobules VI and VII in AutismNew England Journal of Medicine, 1988