The selective solvation of the hyaluronic acid complex of ox synovial fluid

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Abstract
The sedimentation of hyaluronic acid complex (of ox synovial fluid) was observed in solutions containing various concentrations of serum albumin. The hyaluronic acid sediments downward in concentrations of albumin of 9 g/100 ml and below, but upward in a concentration of 12 g/100 ml. Hyaluronic acid complex will therefore sediment at zero rate in a uniform concentration of albumin of about 10 g/100 ml. This indicates a selective solvation of the complex by solvent free of albumin, or a volume inpenetrable by albumin, of about 12 ml/g of hyaluronic acid. This quantity is far lower than that suggested by Johnston (1955). The selective solvation is considerably less in sucrose.