Impact of Body Mass Index on Survival of Patients With Surgically Treated Renal Cell Carcinoma
- 1 January 2006
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 175 (1), 46-52
- https://doi.org/10.1016/s0022-5347(05)00054-6
Abstract
Population studies link increased BMI with an increased risk of cancer and cancer mortality and in particular a greater risk of RCC. We evaluated the impact of BMI and other clinical/pathological characteristics on survival in patients with RCC treated with radical or partial nephrectomy. Between 1995 and 2003 patients undergoing radical (760) or partial (399) nephrectomy for RCC were entered into a database. BMI data were available on 1,137 of 1,159 (98%). Demographic and clinical/pathological parameters were analyzed. World Health Organization BMI definitions (normal—less than 25 kg/m2, overweight—25 to 29.9 kg/m2, obese—30 kg/m2 or more) were used. A total of 75% of patients had greater than normal BMI with 472 (41.5%) overweight and 387 (34.0%) obese. Median followup was 33 months with a median overall survival of 110 months and a 5-year overall survival probability of 0.79. BMI categories were similar in age, gender, smoking status, presenting symptoms, tumor size, stage, and type of surgery. Significant increases in blood loss and operative time (p 2 or greater was associated with a higher proportion of clear cell histology (p = 0.002), it did not translate into an increased pathological stage, or incidence of metastasis. Multivariate analysis revealed age older than 65 years, systemic symptoms, surgery type, and pathological stage impacted overall survival (p <0.05). Although an increased BMI was associated with a greater proportion of clear cell histology, comorbidity, and surgical morbidity, BMI did not adversely impact overall or progression-free survival.Keywords
This publication has 13 references indexed in Scilit:
- A POSTOPERATIVE PROGNOSTIC NOMOGRAM PREDICTING RECURRENCE FOR PATIENTS WITH CONVENTIONAL CLEAR CELL RENAL CELL CARCINOMAJournal of Urology, 2005
- Use of the University of California Los Angeles Integrated Staging System to Predict Survival in Renal Cell Carcinoma: An International Multicenter StudyJournal of Clinical Oncology, 2004
- Risk factors for adult renal cell carcinomaUrologic Clinics of North America, 2004
- Association of Obesity and Cancer Risk in CanadaAmerican Journal of Epidemiology, 2004
- Prognostic value of body mass index in patients undergoing nephrectomy for localized renal tumorsUrology, 2004
- Do patients with a higher body mass index have a greater risk of advanced-stage renal cell carcinoma?Urology, 2003
- Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. AdultsNew England Journal of Medicine, 2003
- A POSTOPERATIVE PROGNOSTIC NOMOGRAM FOR RENAL CELL CARCINOMAJournal of Urology, 2001
- A prospective study of obesity and cancer risk (Sweden)Cancer Causes and Control, 2001
- Later recurrence and longer survival among obese patients with renal cell carcinomaCancer, 1991