Gnetol as a Potent Tyrosinase Inhibitor from GenusGnetum
- 1 January 2003
- journal article
- Published by Informa UK Limited in Bioscience, Biotechnology, and Biochemistry
- Vol. 67 (3), 663-665
- https://doi.org/10.1271/bbb.67.663
Abstract
Gnetol (2,3′,5′,6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 μM) was stronger than kojic acid (IC50, 139 μM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed melanin biosynthesis in murine B16 melanoma cells.Keywords
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