Casein haplotypes and their association with milk production traits in Norwegian Red cattle
Open Access
- 20 February 2009
- journal article
- Published by Springer Science and Business Media LLC in Genetics Selection Evolution
- Vol. 41 (1), 24
- https://doi.org/10.1186/1297-9686-41-24
Abstract
A high resolution SNP map was constructed for the bovine casein region to identify haplotype structures and study associations with milk traits in Norwegian Red cattle. Our analyses suggest separation of the casein cluster into two haplotype blocks, one consisting of the CSN1S1, CSN2 and CSN1S2 genes and another one consisting of the CSN3 gene. Highly significant associations with both protein and milk yield were found for both single SNPs and haplotypes within the CSN1S1-CSN2-CSN1S2 haplotype block. In contrast, no significant association was found for single SNPs or haplotypes within the CSN3 block. Our results point towards CSN2 and CSN1S2 as the most likely loci harbouring the underlying causative DNA variation. In our study, the most significant results were found for the SNP CSN2_67 with the C allele consistently associated with both higher protein and milk yields. CSN2_67 calls a C to an A substitution at codon 67 in β-casein gene resulting in histidine replacing proline in the amino acid sequence. This polymorphism determines the protein variants A1/B (CSN2_67 A allele) versus A2/A3 (CSN2_67 C allele). Other studies have suggested that a high consumption of A1/B milk may affect human health by increasing the risk of diabetes and heart diseases. Altogether these results argue for an increase in the frequency of the CSN2_67 C allele or haplotypes containing this allele in the Norwegian Red cattle population by selective breeding.Keywords
This publication has 33 references indexed in Scilit:
- Construction of a dense SNP map for bovine chromosome 6 to assist the assembly of the bovine genome sequenceAnimal Genetics, 2008
- Genetic support for a quantitative trait nucleotide in the ABCG2 gene affecting milk composition of dairy cattleBMC Genomic Data, 2007
- Effects on Production Traits of Haplotypes Among Casein Genes in Norwegian Goats and Evidence for a Site of Preferential RecombinationGenetics, 2006
- Mapping of a Milk Production Quantitative Trait Locus to a 420-kb Region on Bovine Chromosome 6Genetics, 2005
- Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 2004
- A Comparison of Bayesian Methods for Haplotype Reconstruction from Population Genotype DataAmerican Journal of Human Genetics, 2003
- Relation of β-casomorphin to apnea in sudden infant death syndromePeptides, 2003
- The impact of genetic polymorphisms on the protein composition of ruminant milksReproduction Nutrition Development, 2002
- The complete sequence of the gene encoding bovine α2-caseinGene, 1993
- Structural relatedness ofκ-casein and fibrinogenγ-chainJournal of Molecular Evolution, 1978