Right coronary artery flow impairment in patients with pulmonary hypertension

Abstract

Aims This study investigates whether increased right ventricular (RV) pressure in pulmonary hypertension (PH) impairs right coronary artery (RCA) flow and RV perfusion. Methods In 25 subjects, five patients with idiopathic pulmonary arterial hypertension, nine patients with chronic thromboembolic pulmonary arterial hypertension, and 11 healthy controls, flow of the RCA and left anterior descending (LAD) artery was measured with MR flow quantification. Results In PH, RCA peak systolic and mean systolic flow were lower, 1.02 ± 0.62 mL/s and 0.42 ± 0.30 mL/s, than peak and mean diastolic flow, 2.99 ± 1.97 mL/s ( P < 0.001) and 1.73 ± 0.97 mL/s ( P < 0.001); a pattern similar to the LAD. In contrast, in controls, RCA peak and mean flow in systole, 1.63 ± 0.58 mL/s and 0.72 ± 0.23 mL/s, were comparable to peak and mean flow in diastole, 1.72 ± 0.48 mL/s and 0.93 ± 0.28 mL/s (NS). The systolic-to-diastolic flow ratio in the RCA, and mean flow per gram RV tissue, were inversely related to RV mass, R = −0.61 ( P = 0.009), and R = −0.73 ( P < 0.001) and to RV pressure, R = −0.83 ( P < 0.001), and R = −0.57 ( P = 0.033). Conclusion Although in controls, RCA flow is similar in systole and diastole, in PH there is systolic flow impediment, which is proportional to RV pressure and mass. In patients with severe RV hypertrophy total mean flow is reduced.