Phencyclidine: Tissue Distribution in the Rat
- 1 January 1976
- journal article
- research article
- Published by Informa UK Limited in Clinical Toxicology
- Vol. 9 (4), 573-582
- https://doi.org/10.3109/15563657608988159
Abstract
This study was performed to provide knowledge of the tissue distribution of phencyclidine and has demonstrated the lipophilic nature of the drug. The distribution of phencyclidine in blood, brain, and adipose tissue of rats has been determined at various time intervals during a 48-hr period. The affinity of phencyclidine for adipose tissue and the demonstration of the presence of this drug in brain tissue long after it is no longer detectable in blood provides some correlation between the tissue distribution of phencyclidine and its clinical manifestations occuring 24-48 hr after administration.Keywords
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