Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome
Open Access
- 19 April 2020
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 34 (6), 7404-7426
- https://doi.org/10.1096/fj.202000283rr
Abstract
Fragile X syndrome (FXS) is the leading known inherited intellectual disability and the most common genetic cause of autism. The full mutation results in transcriptional silencing of the Fmr1 gene an...Keywords
Funding Information
- National Institute of Neurological Disorders and Stroke (R01NS112706, R01NS112706, R01NS081746, R37NS045876)
- National Institute of Environmental Health Sciences (P30 ES009089)
- National Institute on Alcohol Abuse and Alcoholism (R01AA027108)
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