The role of lipid droplets in metabolic disease in rodents and humans
Top Cited Papers
Open Access
- 1 June 2011
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 121 (6), 2102-2110
- https://doi.org/10.1172/jci46069
Abstract
Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.Keywords
This publication has 137 references indexed in Scilit:
- Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat storesProgress in Lipid Research, 2011
- β3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNKBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
- The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride LipaseCell Metabolism, 2010
- Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndromeDiabetes Research and Clinical Practice, 2009
- Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDECEMBO Molecular Medicine, 2009
- The life of lipid dropletsBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2008
- Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytesJournal of Cellular Biochemistry, 2008
- Hepatic Steatosis in Leptin-Deficient Mice Is Promoted by the PPARγ Target Gene Fsp27Cell Metabolism, 2008
- Selective versus Total Insulin Resistance: A Pathogenic ParadoxCell Metabolism, 2008
- The Lipid-Droplet Proteome Reveals that Droplets Are a Protein-Storage DepotCurrent Biology, 2006