The Nutritional Requirements of Haemophilus pertussis
Open Access
- 1 August 1955
- journal article
- research article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 13 (1), 1-8
- https://doi.org/10.1099/00221287-13-1-1
Abstract
SUMMARY: Human luteinizing hormone (hLH) and the GTP analogue guanosine 5′-O-(3-thio)triphosphate stimulated morphogenesis in the dimorphic fungal pathogen Candida albicans. hLH bound specifically to subcellular fractions from C. albicans and stimulated adenylate cyclase activity in C. albicans microsomes. We provide the first demonstration of guanine-nucleotide-binding proteins (G-proteins) in C. albicans, and propose that the stimulation of C. albicans morphogenesis by hLH is mediated by a receptor-coupled adenylate cyclase system involving G-proteins.Keywords
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