ACTION OF INSULIN ON THE MOTILITY OF THE GASTROINTESTINAL TRACT

Abstract

Subcutaneous injections of insulin (12-20 units) usually produces in normal human subjects fasting 11-44 hrs. an increase in gastric motility as recorded by the triple balloon method. Gastric tone was also increased and the hunger period was prolonged. Many factors which inhibit ordinary hunger contractions were in this case ineffective, but the insulin response was inhibited by introduction of sugar into the duodenum and also by subcutaneous injection of atro-pine or epinephrin.