H‐2‐linked Gene(s) Influence the Granulomatous Reaction to Viable Mycobacterium lepraemurium in the Mouse
- 1 July 1983
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 18 (1), 59-63
- https://doi.org/10.1111/j.1365-3083.1983.tb00836.x
Abstract
The genetic control of the granulomatous response to viable Mycobacterium lepraemurium (MLM) was studied in C3H and C57BL/6 inbred strains, BXH recombinant inbred strains, (C3H X C57BL) F1 hybrids, and backcross mice. The results indicate that an autosomal dominant gene, or linked complex of genes, has a marked influence on the footpad reaction to viable MLM. The distribution of responders and non-responders among 12 BXH recombinant inbred strains and linkage analysis in C3H X (C3H X C57BL)F1 backcross mice indicated that the response gene(s) are linked to the H-2 complex on chromosome 17. The same gene(s) also influence host restriction of MLM multiplication and thus appear to be the first H-2-linked gene(s) influencing resistance to a bacterial infection.Keywords
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