In vitroantimicrobial activity of hydroxy and N4‐acetyl sulphonamide metabolites
Open Access
- 1 January 1985
- journal article
- other
- Published by Informa UK Limited in Veterinary Quarterly
- Vol. 7 (1), 70-72
- https://doi.org/10.1080/01652176.1985.9693956
Abstract
Hydroxylated metabolites of sulphadimidine, sulphamerazine, sulphatroxazole, sulphamethoxazole, and sulphadiazine exhibited antimicrobial activity against Escheria coli 28 PR 271 test strain ranging from 2.5 to 39.5 per cent of that of the parent drug. Trimethoprim addition potentiated the antimicrobial activity of these metabolites. N4‐acetyl sulphonamide metabolites possessed no antimicrobial activity, nor did trimethoprim potentiated them.Keywords
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