CENTROSOMES IN CELLULAR REGULATION
- 1 November 2005
- journal article
- review article
- Published by Annual Reviews in Annual Review of Cell and Developmental Biology
- Vol. 21 (1), 411-434
- https://doi.org/10.1146/annurev.cellbio.21.122303.120418
Abstract
Centrosomes, spindle pole bodies, and related structures in other organisms are a morphologically diverse group of organelles that share a common ability to nucleate and organize microtubules and are thus referred to as microtubule organizing centers or MTOCs. Features associated with MTOCs include organization of mitotic spindles, formation of primary cilia, progression through cytokinesis, and self-duplication once per cell cycle. Centrosomes bind more than 100 regulatory proteins, whose identities suggest roles in a multitude of cellular functions. In fact, recent work has shown that MTOCs are required for several regulatory functions including cell cycle transitions, cellular responses to stress, and organization of signal transduction pathways. These new liaisons between MTOCs and cellular regulation are the focus of this review. Elucidation of these and other previously unappreciated centrosome functions promises to yield exciting scientific discovery for some time to come.Keywords
This publication has 98 references indexed in Scilit:
- Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidyOncogene, 2004
- Linked for life: temporal and spatial coordination of late mitotic eventsCurrent Opinion in Cell Biology, 2004
- The Salvador partner Hippo promotes apoptosis and cell-cycle exit in DrosophilaNature, 2003
- The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes ApoptosisCell, 2003
- Drosophila Checkpoint Kinase 2 Couples Centrosome Function and Spindle Assembly to Genomic IntegrityCell, 2003
- DNA Damage during Mitosis in Human Cells Delays the Metaphase/Anaphase Transition via the Spindle-Assembly CheckpointCurrent Biology, 2002
- Arrest of cell cycle progression during first interphase in murine zygotes microinjected with anti‐PCM‐1 antibodiesCell Motility, 2002
- Regulation of the Bub2/Bfa1 GAP Complex by Cdc5 and Cell Cycle CheckpointsCell, 2001
- The PACT domain, a conserved centrosomal targeting motif in the coiled‐coil proteins AKAP450 and pericentrinEMBO Reports, 2000
- DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryosNature, 2000