Radiation responses of cancer stem cells
- 21 July 2009
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 108 (2), 339-342
- https://doi.org/10.1002/jcb.22275
Abstract
Recent experimental evidence indicates that many solid cancers have a hierarchical organization structure with a subpopulation of cancer stem cells (CSCs). The ability to identify CSCs prospectively now allows for testing the responses of CSCs to treatment modalities like radiation therapy. Initial studies have found CSCs in glioma and breast cancer relatively resistant to ionizing radiation and possible mechanisms behind this resistance have been explored. This review summarizes the landmark publications in this young field with an emphasis on the radiation responses of CSCs. The existence of CSCs in solid cancers place restrictions on the interpretation of many radiobiological observations, while explaining others. The fact that these cells may be a relatively quiescent subpopulation that are metabolically distinct from the other cells in the tumor has implications for both imaging and therapy of cancer. This is particularly true for biological targeting of cancer for enhanced radiotherapeutic benefit, which must consider whether the unique properties of this subpopulation allow it to avoid such therapies. J. Cell. Biochem. 108: 339–342, 2009.Keywords
This publication has 40 references indexed in Scilit:
- Ionizing Radiation Shifts the PAI-1/ID-1 Balance and Activates Notch Signaling in Endothelial CellsInternational Journal of Radiation Oncology*Biology*Physics, 2009
- Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse ModelCancer Cell, 2009
- Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma MultiformeClinical Cancer Research, 2008
- Cancer induction by restriction of oncogene expression to the stem cell compartmentThe EMBO Journal, 2008
- Identification of CD133-Positive Radioresistant Cells in Atypical Teratoid/ Rhabdoid TumorPLOS ONE, 2008
- PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivoGenes & Development, 2008
- Identification of cells initiating human melanomasNature, 2008
- Isolation and Molecular Characterization of Cancer Stem Cells in MMTV-Wnt-1 Murine Breast TumorsThe International Journal of Cell Cloning, 2007
- ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical OutcomeCell Stem Cell, 2007
- "Destemming" Cancer Stem CellsJNCI Journal of the National Cancer Institute, 2007