Interleukin-22: Immunobiology and Pathology
Top Cited Papers
- 21 March 2015
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 33 (1), 747-785
- https://doi.org/10.1146/annurev-immunol-032414-112123
Abstract
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has evolved rapidly since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues, including the intestines, lung, liver, kidney, thymus, pancreas, and skin. IL-22 primarily targets nonhematopoietic epithelial and stromal cells, where it can promote proliferation and play a role in tissue regeneration. In addition, IL-22 regulates host defense at barrier surfaces. However, IL-22 has also been linked to several conditions involving inflammatory tissue pathology. In this review, we assess the current understanding of this cytokine, including its physiologic and pathologic effects on epithelial cell function.Keywords
This publication has 390 references indexed in Scilit:
- Lymphotoxin Controls the IL-22 Protection Pathway in Gut Innate Lymphoid Cells during Mucosal Pathogen ChallengeCell Host & Microbe, 2011
- In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progressionHepatology, 2011
- CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the GutImmunity, 2010
- Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate LymphocytesImmunity, 2010
- Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3Hepatology, 2010
- Emerging strategies to boost thymic functionCurrent Opinion in Pharmacology, 2010
- E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated ColitisImmunity, 2010
- The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathwaysBiochemical Pharmacology, 2008
- Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γImmunity, 2008
- Interleukin-22 but Not Interleukin-17 Provides Protection to Hepatocytes during Acute Liver InflammationImmunity, 2007