The Quantitative Effect of 0.5% Ketorolac Tromethamine Solution and 0.1% Dexamethasone Sodium Phosphate Solution on Postsurgical Blood-Aqueous Barrier
- 1 April 1988
- journal article
- research article
- Published by American Medical Association (AMA) in American Journal of Ophthalmology
- Vol. 106 (4), 480-483
- https://doi.org/10.1001/archopht.1988.01060130526028
Abstract
• Anterior chamber fluorophotometry was performed after the oral administration of fluorescein sodium in patients undergoing extracapsular cataract extraction and posterior chamber intraocular lens insertion before and after surgery. The administration of 0.5% ketorolac tromethamine solution (ketorolac solution) eye drops before and after surgery decreased the breakdown of the blood-aqueous barrier as compared with 0.1% dexamethasone sodium phosphate solution (dexamethasone solution) eye drops at each period, as measured by fluorophotometry. A single injection below Tenon's capsule of a short-acting corticosteroid had been given to each patient at the end of each surgical procedure. Slit-lamp observations of postoperative ocular inflammation were not different between treatment groups. Both ketorolac and dexamethasone solutions were well tolerated by patients. Ketorolac solution was more effective than dexamethasone solution in facilitating reestablishment of the blood-aqueous barrier after surgery, as measured by fluorophotometry, and was equal to dexamethasone solution as observed by slit-lamp observations. This study suggests that ketorolac ophthalmic solution may be effective and safe as a nonsteroidal anti-inflammatory agent for topical use after cataract surgery and intraocular lens implantation in place of topically administered corticosteroids.This publication has 3 references indexed in Scilit:
- Quantitative Assessment of Postsurgical Breakdown of the Blood-Aqueous Barrier Following Administration of 0.5% Ketorolac Tromethamine SolutionAmerican Journal of Ophthalmology, 1988
- Breakdown and Reestablishment of Blood-Aqueous Barrier With Implant SurgeryAmerican Journal of Ophthalmology, 1982
- Ocular Penetration in Rabbits of Topically Applied DexamethasoneAmerican Journal of Ophthalmology, 1974