CHLORPROMAZINE INHIBITS CHOLERA TOXIN-INDUCED INTESTINAL HYPERSECRETION
- 1 January 1977
- journal article
- research article
- Vol. 55 (3), 126-129
Abstract
The effect of chlorpromazine on cholera-toxin-induced intestinal fluid secretion (experimental cholera) was tested in vivo in the mouse. Injection of chlorpromazine i.m. 1 h prior to toxin challenge effectively inhibits net secretory response of the intestine. This effect might be due to inhibition of adenylate cyclase, since chlorpromazine inhibits increase of cyclic AMP concentration in vitro in mouse thymocytes incubated with cholera toxin.This publication has 3 references indexed in Scilit:
- Interaction of cholera toxin and its subunits with lymphocytesExperimental Cell Research, 1976
- Intestinal myoelectric activity in response to live Vibrio cholerae and cholera enterotoxin.JCI Insight, 1976
- INFLUENCE OF CHEMICAL AGENTS ON ACCUMULATION OF ADENOSINE 3',5'-PHOSPHATE IN SLICES OF RABBIT CEREBELLUM1968