Defining Adult Stem Cells by Function, not by Phenotype
Top Cited Papers
- 1 January 2018
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 87 (1), 1015-1027
- https://doi.org/10.1146/annurev-biochem-062917-012341
Abstract
Central to the classical hematopoietic stem cell (HSC) paradigm is the concept that the maintenance of blood cell numbers is exclusively executed by a discrete physical entity: the transplantable HSC. The HSC paradigm has served as a stereotypic template in stem cell biology, yet the search for rare, hardwired professional stem cells has remained futile in most other tissues. In a more open approach, the focus on the search for stem cells as a physical entity may need to be replaced by the search for stem cell function, operationally defined as the ability of an organ to replace lost cells. The nature of such a cell may be different under steady state conditions and during tissue repair. We discuss emerging examples including the renewal strategies of the skin, gut epithelium, liver, lung, and mammary gland in comparison with those of the hematopoietic system. While certain key housekeeping and developmental signaling pathways are shared between different stem cell systems, there may be no general, deeper principles underlying the renewal mechanisms of the various individual tissues.Keywords
This publication has 72 references indexed in Scilit:
- The Interfollicular Epidermis of Adult Mouse Tail Comprises Two Distinct Cell Lineages that Are Differentially Regulated by Wnt, Edaradd, and Lrig1Stem Cell Reports, 2013
- Distinct contribution of stem and progenitor cells to epidermal maintenanceNature, 2012
- Tissue-Specific Stem Cells: Lessons from the Skeletal Muscle Satellite CellCell Stem Cell, 2012
- Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem CellsCell, 2010
- Mouse Germ Line Stem Cells Undergo Rapid and Stochastic TurnoverCell Stem Cell, 2010
- Epidermal stem cell diversity and quiescenceEMBO Molecular Medicine, 2009
- The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, EpitheliumCell Stem Cell, 2009
- Hematopoiesis: An Evolving Paradigm for Stem Cell BiologyCell, 2008
- Generation of a functional mammary gland from a single stem cellNature, 2006
- Purification and unique properties of mammary epithelial stem cellsNature, 2006