Transplantable Immunoglobulin-Secreting Tumors in Rats. V. Monoclonal Immunoglobulins Secreted by 250 Ileocecal Immunocytomas in LOU/Wsl Rats2

Abstract

Ileocecal immunocytomas spontaneously occurred in 23%of LOU/C/Wsl rats. Of 250 immunocytomas appearing consecutively, 184 secreted monoclonal immunoglobulins including Bence Jones proteins. The monoclonal components were distributed as follows among the 7 different rat immunoglobulins: 3.3% for IgM, 0.6% for IgA, 34.2% for IgE, 35.9% for IgG1, 6.0% for IgG^2a, 0.6% for IgG_2b, and 6.0% for IgG^2c. Most tumors retained their biosrnthetic activity when transplanted.