Correlation of Immunologic and Structural Heterogeneity of Bence Jones Proteins

Abstract

Immunologic differences among Bence Jones proteins within each major type have been correlated with the peptide maps of individual proteins. The findings suggest that single peptide differences among different proteins of the same immunologic type may determine some of the subtype heterogeneity. The theoretical relationship of this heterogeneity to the mutable amino terminal end of the molecules is discussed.