Effect of the benzodiazepine antagonist Ro 15-1788 on flunitrazepam- induced sleep changes.
- 1 May 1983
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 15 (5), 529-536
- https://doi.org/10.1111/j.1365-2125.1983.tb02086.x
Abstract
1 The modifications of human sleep induced by benzodiazepines, and particularly by flunitrazepam, are complex. Stage 4 and paradoxical sleep are both decreased; however, these two effects have a different evolution during and after single or short‐term drug administration. 2 The benzodiazepine antagonist Ro 15‐1788 also tends to depress stage 4, but with immediate recovery in the post‐drug night, and does not modify paradoxical sleep. 3 In combined administration, this drug totally reverses the hypnogenic effect of flunitrazepam, as well as its effect on paradoxical sleep but not the decrease of slow wave sleep. 4 Some of the benzodiazepine‐induced alterations of sleep may be related to receptors different from central benzodiazepine receptors, or to mechanisms not directly connected to this type of receptors.This publication has 20 references indexed in Scilit:
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