The Effect of a Continuous Intravenous Infusion of Inorganic Phosphate on the Rachitic Lesions in Cystinosis

Abstract

Continuous intravenous infusion of inorganic phosphate, causing a substantial rise in serum phosphorus, led to improvement of the rachitic lesions in a 9-month-old boy, suffering from cystinosis. This shows that the disturbance of calcification in this disease is the result of a deranged metabolism of calcium and phosphate, as in other less complicated types of rickets. The data obtained are discussed with reference to the modern concepts of the mechanism of calcification.