Human Prion Protein cDNA: Molecular Cloning, Chromosomal Mapping, and Biological Implications
- 18 July 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 233 (4761), 364-367
- https://doi.org/10.1126/science.3014653
Abstract
A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.Keywords
This publication has 27 references indexed in Scilit:
- Down Syndrome—Alzheimer's LinkedScience, 1985
- Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brainNature, 1985
- A cellular gene encodes scrapie PrP 27-30 proteinCell, 1985
- Molecular characteristics of the major scrapie prion proteinBiochemistry, 1984
- Remarkable conservation of structure among intermediate filament genesCell, 1984
- Purification and structural studies of a major scrapie prion proteinCell, 1984
- Scrapie prions aggregate to form amyloid-like birefringent rodsCell, 1983
- A simple method for displaying the hydropathic character of a proteinJournal of Molecular Biology, 1982
- Novel Proteinaceous Infectious Particles Cause ScrapieScience, 1982
- Measurement of the scrapie agent using an incubation time interval assayAnnals of Neurology, 1982