The Effect of Peptone and Amino Acid Ingestion upon the Concentrations of Tissue Amino Acids
- 1 October 1952
- journal article
- research article
- Published by Elsevier BV in Journal of Nutrition
- Vol. 48 (2), 139-148
- https://doi.org/10.1093/jn/48.2.139
Abstract
At various intervals of time following the ingestion of relatively large quantities of peptone, determinations were made in rats of the concentrations of 9 individual free amino acids in femoral muscle, liver, kidney, and spleen. In addition, measurements were made of variations in the individual non-protein bound amino acids of these tissues. The results indicate that the concentrations of individual amino acids within a single tissue undergo independent changes in response to the ingestion of peptone. Supplementation of normal diets with large quantities of dl-methionine resulted in increased concentrations of methionine in plasma and muscle, but lower levels in kidney and liver tissue. Arginine and phenylalanine levels also decreased in kidney. On a diet containing high concentrations of dl-phenylalanine, no significant changes occurred in muscle and liver tissue and in plasma; contrary to what occurred on the high methionine diet, the levels of arginine and phenylalanine rose in the kidneys of fasted rats; kidney methionine concentrations did not change appreciably.Keywords
This publication has 11 references indexed in Scilit:
- THE INFLUENCE OF METHIONINE DEFICIENCY ON AMINO ACID METABOLISM IN THE RATJournal of Biological Chemistry, 1950
- A METHOD FOR THE DETERMINATION OF FREE AMINO ACIDS IN RAT ORGANS AND TISSUESPublished by Elsevier BV ,1950
- Untersuchungen über die freien Aminosäuren in der Leber bei verschiedener Ernährung. III. Valin, Leuein, Isoleucin, Methionin, Phenylalanin, Histidin, Arginin, Lysin, Tryptophan, Threonin, Cystin, Tyrosin, Prolin und OxyprolinHelvetica Chimica Acta, 1949
- STUDIES ON AMINO ACID EXCRETION IN MANPublished by Elsevier BV ,1948
- STUDIES ON AMINO ACID EXCRETION IN MAN .1. AMINO ACIDS IN URINE1948
- ICROBIOLOGICAL DETERMINATION OF FREE LEUCINE, ISOLEUCINE, VALINE, AND THREONINE IN DOG PLASMA1945
- A New Salt Mixture for Use in Experimental DietsJournal of Nutrition, 1937