Duodenal carcinoid with cytoplasmic whorls of microfilaments

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Abstract
A unique ultrastructural feature in a duodenal carcinoid is described, namely large juxtanuclear accumulations of microfilaments arranged in whorls. Similar microfilaments are found in the D1 cell of the gastro-entero-pancreatic endocrine system. Apparently identical whorl-like accumulations of filaments were previously described in bronchial cells of hamsters treated with nitrosamines and in human giant cell carcinoma of the lung. The D1 cell may be the cell of origin for the described carcinoid and for the described tumor of the lung.
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