EVIDENCE FOR AUTOREGULATION OF GROWTH HORMONE SECRETION VIA THE CENTRAL NERVOUS SYSTEM
- 1 December 1980
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 107 (6), 2117-2120
- https://doi.org/10.1210/endo-107-6-2117
Abstract
The ability of growth hormone (GH) to regulate its own secretion at the level of the central nervous system was examined in chronically cannulated freely-moving rats. Six-hour GH secretory profiles were obtained from 2 groups of rats administered either normal saline or rat GH via the lateral ventricle of the brain. The typical pulsatile pattern of GH secretion was evident in normal saline-treated control rats with most peak GH values >400 ng/ml. Injection of rat GH (15 yg/10 μl) resulted in a significant suppression in amplitude of GH secretory pulses after an interval of 1 hour and plasma GH levels remained markedly depressed for up to 6 h after injection. Peak GH values did not exceed 76 ng/ml during the latter 3 h of the sampling period. These findings clearly demonstrate that GH can regulate its own secretion via a negative feedback system. Furthermore, the results suggest that the central nervous system is an important site of action for GH autoregulation.Keywords
This publication has 7 references indexed in Scilit:
- Growth hormone stimulates hypothalamic somatostatinLife Sciences, 1979
- Hypothalamic Somatostatin and LH-RH after Hypophysectomy, in Hyper- or Hypo-Thyroidism, and during Anesthesia in RatsExperimental Biology and Medicine, 1978
- Effect of Treatment with Growth Hormone on Somatostatin in the Median Eminence of Hypophysectomized RatsExperimental Biology and Medicine, 1977
- Hypothalamic-Pituitary Vasculature: Evidence for Retrograde Blood Flow in the Pituitary Stalk1Endocrinology, 1977
- Effect of hypophysectomy on hypothalamic somatostatin content in rats.Endocrinologia Japonica, 1976
- Hormonal Properties of Transplanted Pituitary Tumors and Their Relation to the Pituitary GlandEndocrinology, 1966
- Influence of Growth Hormone (GH) on Content of GH in the Pituitaries of Normal RatsExperimental Biology and Medicine, 1966