Estrogenic Regulation of Host Immunity against an Estrogen Receptor–Negative Human Breast Cancer
Open Access
- 1 October 2006
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 12 (19), 5641-5647
- https://doi.org/10.1158/1078-0432.ccr-05-1117
Abstract
Purpose: The risk of developing breast cancer is positively correlated with exposure to increased levels of estrogen and/or an increased duration of estrogen exposure. Many different mechanisms have been proposed to explain the association of estrogens with breast cancer risk; however, the well-documented immune modulatory properties of estrogen have received little attention. In part, this is due to a lack of suitable models for studying this relationship.Keywords
This publication has 43 references indexed in Scilit:
- Inflammation and cancerNature, 2002
- Expression of estrogen receptor subtypes and neuronal nitric oxide synthase in neutrophils from women and men Regulation by estrogenCardiovascular Research, 2002
- Dendritic and Natural Killer Cells Cooperate in the Control/Switch of Innate ImmunityThe Journal of Experimental Medicine, 2002
- Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostateThe Prostate, 2000
- Sex steroid hormones and macrophage functionLife Sciences, 1996
- Human breast cancer cell line xenografts as models of breast cancer — The immunobiologies of recipient mice and the characteristics of several tumorigenic cell linesBreast Cancer Research and Treatment, 1996
- Oestradiol stimulates growth of oestrogen receptor-negative MDA-MB-231 breast cancer cells in immunodeficient mice by reducing cell lossEuropean Journal Of Cancer, 1994
- Control of proliferation of MCF-7 breast cancer cells in a commercial preparation of charcoal-stripped adult bovine serumBreast Cancer Research and Treatment, 1992
- Modulation of natural killer cell activity by tamoxifen in stage I post-menopausal breast cancerEuropean Journal of Cancer and Clinical Oncology, 1987
- Tumors: Wounds That Do Not HealNew England Journal of Medicine, 1986