Study of cutaneous lupus erythematosus by immunohistochemical methods
- 1 May 1968
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 97 (5), 520-526
- https://doi.org/10.1001/archderm.97.5.520
Abstract
Direct immuno-fluorescent staining revealed bound immunoglobulins and complement at the dermal-epidermal junction of involved skin in 10 of 10 patients studied with systemic lupus erythematosus (SLE) and 15 of 16 patients with discoid lupus erythematosus (DLE). Positive results were also obtained in 4 of 8 biopsies of uninvolved skin in SLE; 42 cases of miscellaneous dermatoses were similarly studied with 1 positive result in scleroderma. Circulating antibodies for the dermal-epidermal junction were not detected by indirect immunofluorescent techniques. The pattern of immunofluorescent stains can best be attributed to an antigen-antibody process in the tissue.This publication has 5 references indexed in Scilit:
- Basement zone antibodies in bullous pemphigoidJAMA, 1967
- An immunofluorescent study of the skin lesions in systemic lupus erythematosusArthritis & Rheumatism, 1966
- Gamma2, Gamma1A, and Gamma1M Antinuclear Factors in Human Sera*JCI Insight, 1964
- " BOUND " GLOBULIN IN THE SKIN OF PATIENTS WITH CHRONIC DISCOID LUPUS ERYTHEMATOSUS AND SYSTEMIC LUPUS ERYTHEMATOSUSThe Lancet, 1964
- The Application of the Fluorescent Antibody Technic to the Investigation of Lupus Erythematosus and Various DermatosesJournal of Investigative Dermatology, 1963