Histiocytic/Dendritic Cell Transformation of B-Cell Neoplasms: Pathologic Evidence of Lineage Conversion in Differentiated Hematolymphoid Malignancies
- 1 June 2013
- journal article
- review article
- Published by Archives of Pathology and Laboratory Medicine in Archives Of Pathology & Laboratory Medicine
- Vol. 137 (6), 865-870
- https://doi.org/10.5858/arpa.2012-0104-rs
Abstract
B-cell lymphomas, such as low-grade follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, can transform to histiocytic/dendritic cell sarcoma (H/DS) in rare cases. The diagnosis of this unconventional neoplastic evolution relies on a combination of immunophenotypic analysis and genotypic studies. A genotype identical to that of the primary B-cell neoplasm in a secondary neoplasm with H/DS immunophenotype supports the lineage conversion to H/DS. Putative mechanisms for this unusual phenomenon include dedifferentiation, common immature progenitor, and transdifferentiation models, the latter of which is suggested by clinical laboratory data at the present time. Elucidation of the molecular mechanisms governing this lineage conversion may facilitate the understanding of carcinogenesis of not only hematopoietic but also nonhematolymphoid neoplasms. The clinical outcome of secondary H/DS is dismal, as observed in sporadic cases, and the optimal treatment remains to be determined.This publication has 27 references indexed in Scilit:
- Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven casesLaboratory Investigation, 2011
- Sequential Development of Histiocytic Sarcoma and Diffuse Large B-cell Lymphoma in a Patient With a Remote History of Follicular Lymphoma With Genotypic Evidence of a Clonal RelationshipThe American Journal of Surgical Pathology, 2011
- Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular/genetic evidence suggestive of a ‘transdifferentiation’ during the clonal evolutionLeukemia & Lymphoma, 2010
- Transformation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma to Interdigitating Dendritic Cell SarcomaAmerican Journal of Clinical Pathology, 2009
- Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiationJournal of Hematopathology, 2009
- Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma cloneBlood, 2008
- Thalidomide for the treatment of histiocytic sarcoma after hematopoietic stem cell transplantAmerican Journal of Hematology, 2007
- Reprogramming of Committed T Cell Progenitors to Macrophages and Dendritic Cells by C/EBPα and PU.1 Transcription FactorsImmunity, 2006
- Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163Laboratory Investigation, 2005
- True Histiocytic Lymphoma of the Stomach Associated with Low-grade B-cell Mucosa-associated Lymphoid Tissue (Malt)-type LymphomaThe American Journal of Surgical Pathology, 1996