Expression ofNotch1andHes5in the developing olfactory epithelium
- 1 January 2006
- journal article
- research article
- Published by Informa UK Limited in Acta Oto-Laryngologica
- Vol. 126 (5), 498-502
- https://doi.org/10.1080/00016480500437419
Abstract
Conclusion. Notch signaling pathway may play an important role in the development of the olfactory epithelium (OE). Objectives. To elucidate whether the Notch signaling pathway mediates the developmental processes in the developing OE. Materials and methods. The expression of Notch1 and Hes5 in the developing OE of mice with ages ranging from embryonic day (E) 11 to postnatal day (PN) 14 was examined. Results. As detected by in situ hybridization, Notch1 was expressed in scattered cells located in the basal portion of the embryonic OE and later in the cell layer adjacent to the basal lamina from E11 to PN14. Hes5 was expressed in scattered cells located in the basal portion of the embryonic OE from E11. However, at the late embryonic stage, the number of Hes5-positive cells decreased and after birth distinct Hes5-positive cells were not observed in the OE.Keywords
This publication has 13 references indexed in Scilit:
- Expression patterns of basic helix‐loop‐helix transcription factors define subsets of olfactory progenitor cellsJournal of Comparative Neurology, 2004
- Progenitor cells of the olfactory receptor neuron lineageMicroscopy Research and Technique, 2002
- Expression of Deltex1 during mouse embryogenesis: comparison with Notch1 , 2 and 3 expressionMechanisms of Development, 2001
- Roles of the Basic Helix-Loop-Helix Genes Hes1 and Hes5 in Expansion of Neural Stem Cells of the Developing BrainJournal of Biological Chemistry, 2001
- Notch signaling in the development of the inner ear: Lessons from DrosophilaProceedings of the National Academy of Sciences, 2000
- Expression of Math1 and HES5 in the Cochleae of Wildtype and Jag2 Mutant MiceJournal of the Association for Research in Otolaryngology, 2000
- Globose basal cells are neuronal progenitors in the olfactory epithelium: A lineage analysis using a replication-incompetent retrovirusNeuron, 1994
- Morphological study of the effects of intranasal zinc sulfate irrigation on the mouse olfactory epithelium and olfactory bulbMicroscopy Research and Technique, 1993
- Basal cells in the mouse olfactory epithelium after axotomy: immunohistochemical and electron-microscopic studiesCell and tissue research, 1991
- Regeneration of Sensory Hair Cells After Acoustic TraumaScience, 1988